Ephesus always has been very important for the Christian world since Virgin Mary and many early church leaders such as Saint John the Evangelist and Apostle Paul lived in here.
Three ecumenical councils were held in Ephesus on the years 431, 449, and 475. Christian bishops convened in Ephesus to decide some fundamentals of Christianity.
Pope Benedict XVI, Paul VI, and John Paul II visited Ephesus Ancient City and House of Virgin Mary in Ephesus for these reasons. Today you can visit the House of Virgin Mary nearby Ephesus to see gifts brought by Popes to the Virgin Mary’s House.